HCI Cancer Susceptibility Genes Prior Probabilities of Pathogenicity

BReast CAncer genes database

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Home / Release Notes

Latest Release: Priors V2.0 (7/30/2018)

Priors V2.0 includes the following new features and bug fixes:
(Coordinates in regions below are NT locations in HGVS format.)
  • Priors in the grey zone are capped at 0.5. Region affected: BRCA2[9916, 9975]
  • Priors in reference splice sites of BRCA2's exon10 and 12 are capped at 0.5. Regions affected: BRCA2[794, 796], BRCA2[1907, 1909], BRCA2[6842, 6844], and BRCA2[6935, 6937]
  • Bug fixes corrected priors and/or dn_severity categories upstream or within key domains in both BRCA1 and BRCA2.
  • "Direct Link" feature: priors page for a particular NT or AA can be reached using a URL. For instance,
    hci-priors.hci.utah.edu/PRIORS/BRCA/viewer.php?gene=BRCA2&subs_type=HGVS&nt_pos=796
    See Help page for syntax.
  • Accompany this and all future releases, All Priors Reports will be generated. These are spread sheets that contain priors for all NT bases, as well as a comparison table showing the differences between this release and the most recent previous release, when available. Please contact sean.tavtigian@hci.utah.edu for more information.

See the differences between V2.0 and V1.0 here.

Priors V1.0 (Before 7/30/2018)



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